Can late gadolinium enhancement on cardiovascular magnetic resonance describe cardiac involvement in patients with systemic sarcoidosis and/or suspect of cardiac involvement of sarcoidosis with cardiac symptoms?

Methods Forty-three patients (male/female = 12/31, age 30-78 years) with rule out or suspect of CIS with extracardiac sarcoidosis and suspect of CIS without extracardiac sarcoidosis underwent CMR examination. We diagnosed CIS using Diagnostic Standard and Guideline for Sarcoidosis 2006 of the Japanese Society of Sarcoidosis and Other Granulomatous Disorders (2006 criteria) as a gold standard, and subjects were divided into CIS which including suspect of CIS (s/o CIS) and without CIS. We defined CIS as fully satisfied of 2006 criteria, and s/o CIS as follows; satisfied with 1 major and 1 minor of 2006 criteria of CIS with systemic sarcoidosis findings and satisfied with clinical diagnostic criteria of CIS but lack of systemic sarcoidosis findings. We performed visual segment analysis using standard AHA 17-segments model. The LGE were assessed in each segment, localization (5 patterns: endocardial, midwall, epicardial, transmural, and multiple), distribution (3 types: patchy, linear as within 50% of myocardial thickness and band-like as greater than 50% of myocardial thickness), and signal intensity (2 types; lightly, definitively).